09-P005 The Wilms tumour protein is required for kidney function in adult mice
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منابع مشابه
09-P005 The Wilms tumour protein is required for kidney function in adult mice
Hedgehog (Hh) signaling has been implicated in the development of osteoblasts and osteoclasts whose balanced activities are critical for proper bone formation. Since many mouse mutants in the Hh pathway are embryonic lethal, questions on the exact effects of Hh signaling on osteogenesis remain. Using zebrafish larvae mutant in Indian Hedgehog, patched1, patched2 and suppressor of fused (dre), w...
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OBJECTIVE To identify outcomes and prognostic variables that predict survival outcomes in adult Wilms tumour patients. METHODS We collected data on 128 patients with adult Wilms tumour treated between 1973 and 2006. Six cases from our 2 Canadian centres have not been previously reported. We collected data on the remaining 122 patients from published case reports or case series. Analyzed facto...
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Wilms tumour (WT) is an embryonal tumour that recapitulates kidney development. The normal kidney is formed from two distinct embryological origins: the metanephric mesenchyme (MM) and the ureteric bud (UB). It is generally accepted that WT arises from precursor cells in the MM; however whether UB-equivalent structures participate in tumorigenesis is uncertain. To address the question of the in...
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Hepatocyte growth factor (HGF) and its receptor, Met, are key determinants of distinct developmental processes. Although HGF exerts cardio-protective effects in a number of cardiac pathologies, it remains unknown whether HGF/Met signaling is essential for myocardial development and/or physiological function in adulthood. We therefore investigated the requirement of HGF/Met signaling in cardiomy...
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Mice with germline absence of SEC23B die perinatally, exhibiting massive pancreatic degeneration. We generated mice with tamoxifen-inducible, pancreatic acinar cell-specific Sec23b deletion. Inactivation of Sec23b exclusively in the pancreatic acinar cells of adult mice results in decreased overall pancreatic weights from pancreatic cell loss (decreased pancreatic DNA, RNA, and total protein co...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2009
ISSN: 0925-4773
DOI: 10.1016/j.mod.2009.06.335